Post 10

<div style="-webkit-print-color-adjust: exact; background-color: #fdfdfd; border: 0px; color: #111111; font-family: 'Open Sans', Arial, sans-serif; font-size: 14px; line-height: 20.390625px; margin-bottom: 16px; margin-top: 8px; padding: 0px;"> <strong style="-webkit-print-color-adjust: exact; border: 0px; margin: 0px; padding: 0px;">Further research on one of the pan-negative melanoma samples revealed a fusion between two genes - PAPSS1 and BRAF. Additional analysis of 24 pan-negative samples revealed one other BRAF fusion between the genes TRIM24 and BRAF.</strong></div> <div style="-webkit-print-color-adjust: exact; background-color: #fdfdfd; border: 0px; color: #111111; font-family: 'Open Sans', Arial, sans-serif; font-size: 14px; line-height: 20.390625px; margin-bottom: 16px; margin-top: 8px; padding: 0px;"> The investigators then discovered that both of these BRAF fusions triggered a pathway in melanoma cancer cells called the MAPK signaling pathway.</div> <div style="-webkit-print-color-adjust: exact; background-color: #fdfdfd; border: 0px; color: #111111; font-family: 'Open Sans', Arial, sans-serif; font-size: 14px; line-height: 20.390625px; margin-bottom: 16px; margin-top: 8px; padding: 0px;"> Some of the cancer cells were then treated with vemurafenib - a BRAF inhibitor. Others were treated with trametnib - a drug that erases a protein called MEK in the MAPK pathway.</div> <div style="-webkit-print-color-adjust: exact; background-color: #fdfdfd; border: 0px; color: #111111; font-family: 'Open Sans', Arial, sans-serif; font-size: 14px; line-height: 20.390625px; margin-bottom: 16px; margin-top: 8px; padding: 0px;"> <strong style="-webkit-print-color-adjust: exact; border: 0px; margin: 0px; padding: 0px;">The researchers discovered that the MAPK signaling pathway triggered by the BRAF fusions could be inhibited by trametnib. This indicated that the fusions were able to make melanoma cells sensitive to MEK inhibitors.</strong></div> <div style="-webkit-print-color-adjust: exact; background-color: #fdfdfd; border: 0px; color: #111111; font-family: 'Open Sans', Arial, sans-serif; font-size: 14px; line-height: 20.390625px; margin-bottom: 16px; margin-top: 8px; padding: 0px;"> The MAPK signaling pathway did not show any response to vemurafenib.</div> <div style="-webkit-print-color-adjust: exact; background-color: #fdfdfd; border: 0px; color: #111111; font-family: 'Open Sans', Arial, sans-serif; font-size: 14px; line-height: 20.390625px; margin-bottom: 16px; margin-top: 8px; padding: 0px;"> Prof. Sosman, also an investigator of the Stand up to Cancer Melanoma Dream Team, says the discovery of the BRAF fusions suggest there may already be drugs available to treat these pan-negative melanomas.</div> <div style="-webkit-print-color-adjust: exact; background-color: #fdfdfd; border: 0px; color: #111111; font-family: 'Open Sans', Arial, sans-serif; font-size: 14px; line-height: 20.390625px; margin-bottom: 16px; margin-top: 8px; padding: 0px;"> He explains:</div> <div class="separator" style="clear: both; text-align: center;"> <a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj4AK2afmuKNYaZuauKWiC-VVb6Y2s8c2LnIYdtw2pQPMf5Rv_02tZH2p9AQM56POLsykcoyLA4bz6b9iuaEIvveLAjdMwyHIHzZ0MEdKEgknpL4nAE92nVctT0EsACr656st90YrDngWQJ/s1600/261.jpeg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="320" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEj4AK2afmuKNYaZuauKWiC-VVb6Y2s8c2LnIYdtw2pQPMf5Rv_02tZH2p9AQM56POLsykcoyLA4bz6b9iuaEIvveLAjdMwyHIHzZ0MEdKEgknpL4nAE92nVctT0EsACr656st90YrDngWQJ/s320/261.jpeg" width="249" /></a></div>

Post 10

Further research on one of the pan-negative melanoma samples revealed a fusion between two genes - PAPSS1 and BRAF. Additional analysis of ...

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Post 9

<div style="-webkit-print-color-adjust: exact; background-color: #fdfdfd; border: 0px; color: #111111; font-family: 'Open Sans', Arial, sans-serif; font-size: 14px; line-height: 20.390625px; margin-bottom: 16px; margin-top: 8px; padding: 0px;"> <strong style="-webkit-print-color-adjust: exact; border: 0px; margin: 0px; padding: 0px;">Further research on one of the pan-negative melanoma samples revealed a fusion between two genes - PAPSS1 and BRAF. Additional analysis of 24 pan-negative samples revealed one other BRAF fusion between the genes TRIM24 and BRAF.</strong></div> <div style="-webkit-print-color-adjust: exact; background-color: #fdfdfd; border: 0px; color: #111111; font-family: 'Open Sans', Arial, sans-serif; font-size: 14px; line-height: 20.390625px; margin-bottom: 16px; margin-top: 8px; padding: 0px;"> The investigators then discovered that both of these BRAF fusions triggered a pathway in melanoma cancer cells called the MAPK signaling pathway.</div> <div style="-webkit-print-color-adjust: exact; background-color: #fdfdfd; border: 0px; color: #111111; font-family: 'Open Sans', Arial, sans-serif; font-size: 14px; line-height: 20.390625px; margin-bottom: 16px; margin-top: 8px; padding: 0px;"> Some of the cancer cells were then treated with vemurafenib - a BRAF inhibitor. Others were treated with trametnib - a drug that erases a protein called MEK in the MAPK pathway.</div> <div style="-webkit-print-color-adjust: exact; background-color: #fdfdfd; border: 0px; color: #111111; font-family: 'Open Sans', Arial, sans-serif; font-size: 14px; line-height: 20.390625px; margin-bottom: 16px; margin-top: 8px; padding: 0px;"> <strong style="-webkit-print-color-adjust: exact; border: 0px; margin: 0px; padding: 0px;">The researchers discovered that the MAPK signaling pathway triggered by the BRAF fusions could be inhibited by trametnib. This indicated that the fusions were able to make melanoma cells sensitive to MEK inhibitors.</strong></div> <div style="-webkit-print-color-adjust: exact; background-color: #fdfdfd; border: 0px; color: #111111; font-family: 'Open Sans', Arial, sans-serif; font-size: 14px; line-height: 20.390625px; margin-bottom: 16px; margin-top: 8px; padding: 0px;"> The MAPK signaling pathway did not show any response to vemurafenib.</div> <div style="-webkit-print-color-adjust: exact; background-color: #fdfdfd; border: 0px; color: #111111; font-family: 'Open Sans', Arial, sans-serif; font-size: 14px; line-height: 20.390625px; margin-bottom: 16px; margin-top: 8px; padding: 0px;"> Prof. Sosman, also an investigator of the Stand up to Cancer Melanoma Dream Team, says the discovery of the BRAF fusions suggest there may already be drugs available to treat these pan-negative melanomas.</div> <div style="-webkit-print-color-adjust: exact; background-color: #fdfdfd; border: 0px; color: #111111; font-family: 'Open Sans', Arial, sans-serif; font-size: 14px; line-height: 20.390625px; margin-bottom: 16px; margin-top: 8px; padding: 0px;"> He explains:</div> <div class="separator" style="clear: both; text-align: center;"> <a href="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi3LehVCMsQOQeHJZmYcyAx_Dw_tNK5LKdvtkKPNW131ItbVrH_HgG24LaBqnw_dJElVaz4MP6B9QSAHdyDpjdstYiwV9cPEEt_Qg7Q_fjI3JLqJNSuMNwNpYpN-E4F6029Cp_7DKjdYCif/s1600/153.jpeg" imageanchor="1" style="margin-left: 1em; margin-right: 1em;"><img border="0" height="241" src="https://blogger.googleusercontent.com/img/b/R29vZ2xl/AVvXsEi3LehVCMsQOQeHJZmYcyAx_Dw_tNK5LKdvtkKPNW131ItbVrH_HgG24LaBqnw_dJElVaz4MP6B9QSAHdyDpjdstYiwV9cPEEt_Qg7Q_fjI3JLqJNSuMNwNpYpN-E4F6029Cp_7DKjdYCif/s320/153.jpeg" width="320" /></a></div>

Post 9

Further research on one of the pan-negative melanoma samples revealed a fusion between two genes - PAPSS1 and BRAF. Additional analysis of ...

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